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Pseudomonas; labile in opposition to Gram-constructive and Gram-negative penicillinases temocillin (6-a-methoxy No effect towards Pseudomonas; extremely stable in the ticarcillin) presence of betalactamases Acylureidopenicillins azlocillin, mezlocillin, Effective against Enterobacteriaceae and piperacillin, apalcillin Pseudomonas; despite lability towards beta-lactamases energetic against many enzyme-producing strains because of good penetration and high levels of sensitivity of the target molecules Penems Penicillins with a double bond within the second ring system A carbapenem (C atom as an alternative of sulfur in second N-formimidoyl thienamycin ring); very broad spectrum and high degree of (imipenem = activity against Gram-constructive and Gram-adverse N-F-thienamycin + bacteria, together with anaerobes; regularly efficient cilastatin) in opposition to Enterobacteriaceae and Pseudomonas with resistance to the cephalosporins of Group 3b; inactivated by renal enzymes; is therefore administered in combination with the enzyme inhibitor cilastatin Kayser, Medical Microbiology © 2005 Thieme All rights reserved. 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