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Tese include: > acute sickness > Trauma > Surgery > alcohol (especially beer and wines) > Diuretics, allopurinol 172 Internal Medicine Clinical treatment tips Chapiter 6: Musculoskeletal and Connective Tissues Conditions Intercritical gout пїЅ afer an initial acute attack sufferers may be free of symptoms for months or years; but some go on to have more frequent attacks and some eventually develop persistent tophaceaous gout or everlasting joint injury, or each, depending on diploma of hyperuricaemia Chronic tophaceous gout пїЅ Patients who develop chronic gout usually are those whose hyperuricemia isn't managed пїЅ Crystal deposits (tophi) may develop round palms, ft, elbows, and ears in addition to acutely afected joints Criteria for the scientific diagnosis of gout (American College of rheumatology) Six or more of these criteria are wanted to make a prognosis пїЅ More than one attack of acute arthritis пїЅ Maximum infammation developed within in the future пїЅ assault of monoarthritis пїЅ Redness over joints пїЅ Painful or swollen frst metatarsophalangeal joint пїЅ Unilateral assault on frst metatarsophalangeal joint пїЅ Unilateral attack on tarsal joint пїЅ Tophus (proved or suspected) пїЅ Hyperuricaemia пїЅ asymmetric swelling within a joint on radiograph пїЅ Subcortical cysts without erosions on radiograph пїЅ Joint fuid culture adverse for organisms throughout assault Complications Recurrent gout Tophi in advanced gout Kidney stones Joint harm Psychological efects Investigations 6 Serum urate concentration: Hyperuricemia is defned as a serum or plasma urate concentration higher than 7. 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